OMICS in eye diseases

Eye diseases significantly impact global health burden and pose several challenges due mostly, to their complex and multifactorial nature. The advent of OMICS technologies - genomics, transcriptomics, proteomics, metabolomics, and epigenomics - has revolutionized our understanding of these diseases by providing comprehensive insights into disease mechanisms, progression, and potential therapeutic targets. Genomic studies have identified genetic variants associated with risk, while transcriptomic and proteomic analyses have revealed dysregulated pathways in glaucoma, age-related macular degeneration, and retinopathies, among others. Metabolomic and epigenomic approaches further emphasize the significance of metabolic dysregulation and gene-environment interactions in disease pathogenesis. Integrating multi-OMICS data provides a systems biology perspective, enhancing the understanding of disease mechanisms, the discovery of novel biomarkers, and personalized therapeutic strategies.

This issue will highlight the role of OMICS in ophthalmology, emphasizing its potential to modify the prevention, diagnosis, and management of eye diseases. It also intends to bridge the gap between OMICS-driven discoveries and clinical applications in eye diseases either as independent OMICS or through the integration of multi-OMICS data, bringing together new developments and concepts. The articles in this issue may shed light into the genetic and molecular pathways underlying ocular pathologies and the identification of novel biomarkers and therapeutic targets, enabling the development of personalized treatment strategies.

This issue will provide readers with an overview of studies exploring the role of OMICS technologies, particularly genomics, transcriptomics, proteomics, and epigenomics, in the understanding and potential management of eye diseases. We particularly invite articles focusing on investigating genetic risk factors, molecular mechanisms, and metabolic dysregulation underlying conditions such as glaucoma, ocular surface diseases, age-related macular degeneration, and retinopathies. Studies integrating multi-OMICS data with potential to reveal novel biomarkers, disease pathways, and personalized therapeutic strategies are especially welcome. Authors should provide thorough methodological details and highlight the translational potential of their findings. Interdisciplinary studies integrating computational biology, bioinformatics, and experimental methods are encouraged. Manuscripts must comply with ethical standards and include appropriate validation of results.

Article types

Original Research
Brief Communication
Commentary
Editorial
Mini Review
Review

Article types and fees

This Issue accepts the following article types, unless otherwise specified in the Issue description:

• Brief Communication
• Commentary
• Editorial
• Mini Review
• Original Research
• Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Issue accepts the following article types, unless otherwise specified in the Issue description:

• Brief Communication
• Commentary
• Editorial
• Mini Review
• Original Research
• Review

Keywords: genomics, transcriptomics, proteomics, epigenomics, optic nerve, retina, cornea, ocular surface